Controlled release of 5-fluorouracil from hydrophilic ethylene-vinyl alcohol copolymer matrices.

Characteristics of ethylene vinyl alcohol copolymer (EVAL) mixtures.

PURPOSE To determine physical characteristics of mixtures of ethylene vinyl alcohol copolymer (EVAL) and metrizamide dissolved in dimethyl sulfoxide, liquid materials developed for embolization of arteriovenous malformations. METHODS EVAL and dimethyl sulfoxide were mixed in various proportions and sterilized. The viscosity and density of each mixture was measured. Precipitation times were de...

study of ethylene/vinyl acetate transformation to ethylene/vinyl alcohol copolymer by nmr and dsc

hydrolysis of ethylene-vinyl acetate copolymer in alkaline conditions using two systems of naoh/methanol and koh/isopropanol has been studied and the formation of ethylene-vinyl alcohol copolymer was systematically examined using nmr spectroscopy and dsc measurements. vinyl acetate weight percentage and the degree of hydrolysis were calculated from nmr spectroscopy and it is shown that hydrolys...

Potential Use of Ethylene Vinyl Acetate Copolymer Excipient in Oral Controlled Release Applications: a Literature Review

Ethylene vinyl acetate copolymer (EVA) has a successful commercial history in the pharmaceutical industry as a controlled release excipient. The usage covers a wide spectrum of parenteral applications ranging from transdermal drug delivery, contraceptive insertions, subcutaneous implants and mucosal contact forms. The importance and prominence of EVA in parenteral applications has inspired rese...

Modulation of drug release from hydrophilic matrices

The Release Behavior and Kinetic Evaluation of Diltiazem HCl from Various Hydrophilic and Plastic Based Matrices

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...